SUTHERLAND police said it was raining when a Wollongong man, 34, veered onto the wrong side of Heathcote Road at Engadine on Monday night before colliding with another car just before 7.30pm.
He died from fatal head injuries a few hours later at St George Hospital.
The driver of the other car, a man aged 44, was taken to hospital with minor injuries, police said.
The Leader published a front page story in January reporting nine people had died on the 24-kilometre stretch of road in almost five years.
Retired police superintendent Reg Armstrong and his wife Helen were involved in an accident on the road last November.
Mr Armstrong, a police officer for 38 years who was called to about a dozen deaths on Heathcote Road, said at the time he feared the death toll would rise.
He said speed was the biggest contributor to accidents on the road and he believed a combination of dual lanes and a heavier police presence could help stop the deaths.
Sutherland police duty officer Inspector Jason Heyward said his first thoughts when he heard of an accident on Heathcote Road was, 'would it be fatal?'.
"You think: 'It's not going to be pretty. It's going to be another fatal'," Inspector Heyward said.
"People should take it easy when they are travelling on that road in particular."
Inspector Heyward said the most recent accident occurred about 2.5 kilometres from the Princes Highway, just before the Woronora Bridge.
"The deceased's car spun out of control and [the driver of] the other car tried to brake but could not avoid it," he said.
"It was raining at the time and there was poor visibility."
Police from the crash investigation unit are asking for anyone who saw the accident or its lead up to contact police.
Crime Stoppers, 1800 333 000.
What will stop the deaths on Heathcote Road?