Lawrence Hargrave Drive at Stanwell Park will be closed in both directions on Monday night next week for essential maintenance work between Lady Wakehurst Drive and Railway Crescent.
Work will be carried out between 8pm on Monday, February 18 and 4am on Tuesday, February 19, weather permitting.
Heathcote MP Lee Evans said work would include clearing gutters and drains to improve water runoff, maintaining vegetation, guardrail and maintenance of signs to improve safety for motorists
Detours will be in place via the M1 Princes Motorway and Bulli Pass, and motorists should allow up to 30 minutes additional travel time.