Captain Cook Drive is now closed in both directions.
Light vehicles are being diverted via local streets while heavy vehicles are advised to avoid the area as there is no suitable diversion.
A truck has lost its load at Caringbah on Friday morning, causing a major clean-up and road closures.
One of two eastbound lanes is closed on Captain Cook Drive at Gannons Rd due to the crash.
The truck rolled at the round-a-bout. It was carrying demolition material including plasterboards.
One lane is expected to remain closed until the truck is salvaged and the clean-up is complete.
Traffic is heavy and drivers are urged to allow extra travel time in the area.