Premier among first to receive jab at St George Hospital's new COVID-19 vaccination hub

Health Minister Brad Hazzard and NSW Chief Health Officer Kerry Chant were also vaccinated on the opening day of the hospital's coronavirus vaccination hub, which will initially be for people working on the front line.

The show of confidence came as NSW recorded its 52nd consecutive day without a locally transmitted case and Dr Chant was honoured for her efforts in the war against the virus by being named NSW Woman of the Year.

From today (Wednesday), the AstraZeneca vaccine is being administered at St George Hospital and Hornsby Hospital.

The Pfizer vaccine has been given at Royal Prince Alfred, Westmead and Liverpool hospitals for the last three weeks, and hospital staff from St George and Sutherland Shire have been transported to those centres to receive it.

At a media conference in the grounds of St George Hospital before the trio was vaccinated, Ms Berejiklian said feedback from those who have been vaccinated has been "absolutely positive".

Ms Berejiklian said she was told there "were virtually no 'no shows' in people coming forward".

"The vast majority of people are very enthusiastic and the responses are very positive," she said.

Ms Berejiklian said 27,000 people in NSW had so far been vaccinated through the state health system and NSW was on track to reach its target of 35,000 first-dose vaccinations in the first three weeks of the program.

The Premier said the effectiveness of both drugs had been found to be about the same.

Ms Berejiklian said, while the state's responsibility in the national vaccination program was limited at this stage to priority groups, an offer had been made to the federal government to continue vaccinations for the general public from almost 100 state-run hospital clinics.

This would supplement the plan for the vaccine to be mostly administered by GPs.

The Premier said the federal government had yet to respond.

Mr Hazzard said most NSW residents would receive the AstraZeneca vaccine.

"There are very ample supplies coming," he said. "Essentially, AstraZeneca will be rolling over the top of the Pfizer vaccine."

Mr Hazzard said he and the Premier and Dr Chant had "absolute confidence in the vaccine and we are all looking forward to having it".

He advised people not to call GPs asking about vaccinations, as they would not be be able to answer questions about availability until the federal government announced details in the next week or two.

Dr Chant said the Australian health regulator had determined both vaccines were safe and effective.and people should have confidence in coming forward for vaccination.